![]() ![]() In contrast to irreversible replicative senescence of normal cells, a tumor cell senescence-like state induced by oncogenes, chemotherapy, or radiation therapy can be reversed ( 10, 11). Senescent cells can persist for a long time, can activate stemness programs, and acquire higher tumorigenicity than original non-senescent cells ( 9). The DNA damage response induces cell cycle arrest either in the G1 or more often in the G2/M stage of cell cycle ( 8). Senescent cancer cells have enlarged size, accumulation of DNA damage foci, and increased activity of senescence-associated β-galactosidase (SA-β-gal) ( 7). Senescence is a stress response that can be induced by a wide range of intrinsic and extrinsic factors including p53/p21 cip1 pathway, radiation, or chemotherapy ( 6). Cancer cell dormancy encompasses two major conditions: populations maintaining steady state through similar rates of growth and death (population-level dormancy) and single/small population of quiescent cells in a reversible state of cell arrest in which cells retain the ability to re-enter the cell cycle (cellular dormancy) ( 5). Disseminated tumor cells can lie dormant for extended time before initiating tumor outgrowth. Cancer cell dissemination is likely to happen early during primary cancer evolution prior to initial therapy ( 3, 4). Tumor recurrence years after complete surgical resection or complete clinical response to chemotherapy or radiation therapy is one of the major causes of cancer-related deaths ( 1, 2). These observations demonstrate a mechanism linking stress and specific neutrophil activation with early recurrence in cancer. Targeting of S100A8/A9 or β2 adrenergic receptors abrogated stress-induced reactivation of dormant tumor cells. Higher serum concentrations of S100A8/A9 were associated with shorter time to recurrence in patients with lung cancer after complete tumor resection. Upon release from neutrophils these lipids upregulate the fibroblast growth factor pathway in tumor cells, causing tumor cell exit from the dormancy and formation of new tumor lesions. S100A8/A9 induce activation of myeloperoxidase, resulting in accumulation of oxidized lipids in these cells. Stress hormones cause rapid release of pro-inflammatory S100A8/A9 proteins by neutrophils. ![]() Using dormancy models of lung and ovarian cancer, we found a specific mechanism, mediated by stress and neutrophils, that may govern this process. Reactivation of dormant tumor cells is largely responsible for this phenomenon. For example "Beachy Green, The Schnoz, and Lucy Ladies" or "3 of the Watching You".Tumor recurrence years after seemingly successful treatment of primary tumors is one of the major causes of mortality in cancer patients. After you place your order, you will have to enter "personalization" information - simply enter which design you want and how many if you want more than one. And now also available are Hollywood (yellow star glasses), Suspicious Eyes, Googly Eyes, Sad Eyes, Angry Eyes, and Cat Eyes. Check out our photo with the magnet names - Beachy Green (sunglasses), Watching You (cat's eye glasses), Heart Throb (heart glasses), The Schnoz (glasses with nose), The Blues (goggles), Munchers (caterpillar), Flash (snail), Buzz (bee), and Lucky Ladies (pair of ladybugs). Choosing the big set will also get you a little bit of a discount over purchasing them individually. Our magnets come in sets of three and you get to choose which three designs your get - mix and match, or choose three of your favorite! And for those who can't decide which ones to get, we also now offer "The Big Set" which includes one of each of our 15 designs. What is PLA? PLA, also known as polylactic acid or polylactide, is a thermoplastic made from renewable resources such as corn starch, tapioca roots or sugar cane, unlike other industrial materials made primarily from petroleum.ĭue to the small size of these magnets, they are not recommended for use around young children or overly curious pets. Because our plant bling has magnets and a separate backer magnet, it means you can also use them as a cute way to hold notes on your refrigerator, locker, or wherever! As a fun idea, you can get extra magnets and surprise your friends by sneaking them onto their plants when they aren't looking! Especially those “Plant Moms” in your life! Guaranteed to bring a smile to your face every time you see it. ![]() Simply place the magnet on your house plant leaf and then apply the backer magnet on the other side to hold it in place. These 3D printed magnets are the perfect house plant accent! Each one has magnets on the back of them along with a "backer" magnet.
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